4-Bromophenol → 1-Bromo-4-(3-chloropropoxy)benzene

HRID 506188Notes

Reaction equation

[Br:1][C:2]1[CH:7]=[CH:6][C:5](O)=[CH:4][CH:3]=1.[Cl:9][CH:10](C)[CH2:11]OS(C1C=CC(C)=CC=1)(=O)=O.[C:24]([O-:27])([O-])=O.[Cs+].[Cs+]>>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([O:27][CH2:24][CH2:11][CH2:10][Cl:9])=[CH:4][CH:3]=1

Participants

Reactant 3

HCID 78084-Bromophenol

HCID 10796Cesium carbonate

HCID 1082542-Chloropropyl 4-methylbenzene-1-sulfonate

Product 1

HCID 126856091-Bromo-4-(3-chloropropoxy)benzene

Procedure

4-Bromophenol was reacted with 2-chloropropyl-p-toluenesulfonate and Cs2CO3 to give 1-bromo-4-(3-chloropropoxy)benzene.

Sources & evidence

ORD record: ord-3adcea7bd8214a8badd8dd6360edc194
Source dataset: uspto-grants-2010_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07781591B2

Reaction notes

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