HuagongsheHuagongshe Chemistry Print Report · For research reference only
Imidazole → HCID 77737378, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Imidazole | HCID 795 | — |
| Reactant | tert-Butyldimethylsilyl chloride | HCID 28928 | — |
| Reactant | 4-[7-[(2-Phenylcyclopropyl)amino]-5-(propylthio)-3H-[1,2,3]-triazolo[4,5-d]pyrimidin-3-yl]cyclopentane-1,2,3-triol | HCID 77750368 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 77737378 | HCID 77737378 | — |
Reaction Steps
A mixture of the product of step d) (1.79 g), tert-butyldimethylsilylchloride (1.22 g) and imidazole (1.10 g) in N,N-dimethylformamide (3 ml) was stirred at ambient temperature for 24 hours. Further tert-butyldimethylsilylchloride (1.0 g) was added and the mixture stirred for a further 6 hours. The reaction mixture was concentrated in vacuo and the residue purified by chromatography (SiO2, ethyl acetate: hexane 1:20 as eluant) to afford the sub-title compound (2.43 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06713483B1 |
| Source dataset | uspto-grants-2004_03 |
| ORD ID | ord-9648724a95124abdad16259680ca18a0 |
| Source note | uspto-grants-2004_03 |