Citric Acid → Tricalcium Phosphate

HRID 506420Notes

Reaction equation

HRID 506420 reaction equation
C(O)(=O)CC(CC(O)=O)(C(O)=O)O.[OH-].[OH-].[Ca+2:16].[P:17](=[O:21])([OH:20])([OH:19])[OH:18].[OH-].[K+]>>[P:17]([O-:21])([O-:20])([O-:19])=[O:18].[Ca+2:16].[P:17]([O-:21])([O-:20])([O-:19])=[O:18].[Ca+2:16].[Ca+2:16]

Participants

5

Reactant 4

HCID 311Citric AcidHCID 1004Phosphoric AcidHCID 14797Potassium HydroxideHCID 6093208Calcium Hydroxide

Product 1

HCID 24456Tricalcium Phosphate

Procedure

0.05 mol of 50% citric acid was added dropwise to 1 mol of a 11% calcium hydroxide slurry regulated at 15° C. over 300 seconds under stirring, thereafter, a mixture of 0.66 mol of 30% phosphoric acid and 0.05 mol of 40% KOH was added dropwise over 600 seconds and, thereafter, this was stirred at 80° C. for 3 hours to obtain a white slurry. The slurry was concentrated to a solid matter of 50% using an ultracentrifuge, and water was added again to obtain a slurry having-the same concentration as that before concentrated. The aforementioned concentration and re-slurrying were repeated three times to obtain calcium phosphate V. It was confirmed by X-ray diffraction that the resulting white cake is amorphous calcium phosphate.

Workup

  1. additionwas added dropwise over 600 seconds
  2. stirringthis was stirred at 80° C. for 3 hours
  3. customto obtain a white slurry
  4. concentrationThe slurry was concentrated to a solid matter of 50%
  5. additionwas added again
  6. customto obtain a slurry
  7. concentrationhaving-the same concentration as
  8. concentrationthat before concentrated
  9. concentrationThe aforementioned concentration

Sources & evidence

ORD record
ord-57587a0a7b4a4e9e8f970c3148b813ba
Source dataset
uspto-grants-2010_08
Patent number
US07785705B2

Reaction notes

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