2,3-Dihydroxybutanedioate → (1r-trans)-n-[2-(4-Methoxyphenyl)cyclopropyl]acetamide

HRID 50644Notes

Reaction equation

HRID 50644 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([C@@H:9]2[CH2:11][C@H:10]2[NH2:12])=[CH:5][CH:4]=1.[OH:13][CH:14](C(O)C([O-])=O)[C:15]([O-])=O>>[CH3:1][O:2][C:3]1[CH:4]=[CH:5][C:6]([C@@H:9]2[CH2:11][C@H:10]2[NH:12][C:14](=[O:13])[CH3:15])=[CH:7][CH:8]=1

Participants

3

Reactant 2

HCID 38061142,3-DihydroxybutanedioateHCID 10442008(1R,2S)-2-(4-methoxyphenyl)cyclopropanamine

Product 1

HCID 69887991(1r-trans)-n-[2-(4-Methoxyphenyl)cyclopropyl]acetamide

Procedure

The sub-title compound was prepared according to the method of Example 4, step a) from (1R-trans)-2-(4-methoxyphenyl)cyclopropanamine, [R-(R*,R*)]-2,3-dihydroxybutanedioate (1:1) (prepared as described in W09905143) to give a white solid (655 mg).

Sources & evidence

ORD record
ord-3dd25e56c5904d0aa5c5dba4d6757c65
Source dataset
uspto-grants-2004_03
Patent number
US06713483B1

Reaction notes

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