Ammonia → HCID 68420889, compound

HRID 506440Notes

Reaction equation

HRID 506440 reaction equation
[CH:1]1([C:4]2[N:5]=[N:6][S:7][C:8]=2[C:9]([O:11]C)=O)[CH2:3][CH2:2]1.[NH3:13]>CO>[CH:1]1([C:4]2[N:5]=[N:6][S:7][C:8]=2[C:9]([NH2:13])=[O:11])[CH2:3][CH2:2]1

Participants

4

Reactant 2

HCID 222AmmoniaHCID 57659801HCID 57659801, compound

Product 1

HCID 68420889HCID 68420889, compoundYield 55%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Methyl 4-cyclopropyl-1,2,3-thiadiazole-5-carboxylate (2 g; 11 mmols) was dissolved in methanol (5 ml), and aqueous ammonia (5 ml) was added thereto, followed by stirring at room temperature for 1 hour. Subsequently, the reaction mixture was concentrated under reduced pressure, and the residue was washed with hexane to obtain 1 g of 4-cyclopropyl-1,2,3-thiadiazole-5-carboxamide.

Workup

  1. concentrationSubsequently, the reaction mixture was concentrated under reduced pressure
  2. washthe residue was washed with hexane

Sources & evidence

ORD record
ord-a73c15d4c9fe432ead57a56d0e1fe1bc
Source dataset
uspto-grants-2010_08
Patent number
US07786040B2

Reaction notes

Loading…