Triethylamine → HCID 59432160, compound

HRID 506482Notes

Reaction equation

HRID 506482 reaction equation
[F:1][C:2]1[CH:18]=[CH:17][C:5]([C:6]([NH:8][CH:9]([CH:14]2[CH2:16][O:15]2)[C:10]([O:12][CH3:13])=[O:11])=[O:7])=[C:4]([C:19]([F:22])([F:21])[F:20])[CH:3]=1.[F:23][C:24]1[CH:25]=[C:26]([SH:30])[CH:27]=[CH:28][CH:29]=1.C(N(CC)CC)C>CO>[F:23][C:24]1[CH:25]=[C:26]([S:30][CH2:16][CH:14]([OH:15])[CH:9]([NH:8][C:6](=[O:7])[C:5]2[CH:17]=[CH:18][C:2]([F:1])=[CH:3][C:4]=2[C:19]([F:22])([F:21])[F:20])[C:10]([O:12][CH3:13])=[O:11])[CH:27]=[CH:28][CH:29]=1

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 75710m-FluorobenzenethiolHCID 59432161Methyl (4-fluoro-2-trifluoromethylbenzoylamino)oxiranylacetate

Product 1

HCID 59432160HCID 59432160, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

480 mg (1.5 mmol) of methyl (4-fluoro-2-trifluoromethylbenzoylamino)oxiranylacetate were dissolved in methanol, and 215 mg (1.5 mmol) of 3-fluorothiophenol and 280 mg (3.8 mmol) of triethylamine were then added. The mixture was then stirred at RT for 15 h, and the solvent was then removed. This gave 760 mg of diasteromerically pure crude product which was used for the next step without further purification.

Workup

  1. customthe solvent was then removed
  2. customThis gave 760 mg of diasteromerically pure crude product which was used for the next step without further purification

Sources & evidence

ORD record
ord-a9335e86ae4c41e3af571afdedac42c2
Source dataset
uspto-grants-2010_08
Patent number
US07786046B2

Reaction notes

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