HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → Ethyl (4-fluoro-2-trifluoromethylbenzoylamino)acetate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 4-Fluoro-2-(trifluoromethyl)benzoyl chloride | HCID 605680 | — |
| Reactant | Glycine ethyl ester, hydrochloride | HCID 2723640 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | Ethyl (4-fluoro-2-trifluoromethylbenzoylamino)acetate | HCID 59432157 | — |
Reaction Steps
30.7 g (0.22 mol) of ethyl glycinate hydrochloride were suspended in CH2Cl2. At 0° C., 86.3 g (0.854 mol) of triethylamin and 50 g (0.22 mol) of 2-trifluoromethyl-4-fluorobenzoylchlorid dissolved in 250 ml of CH2Cl2 were successively added dropwise. After 48 h at RT, the solution was washed and dried, and the solvent was removed. This gave 62.2 g (97% of theory) of the title compound as a colorless solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07786046B2 |
| Source dataset | uspto-grants-2010_08 |
| ORD ID | ord-8cdcb205cda14b7caf31e1d0b8903b50 |
| Source note | uspto-grants-2010_08 |