反应详情

30.7 g (0.22 mol) of ethyl glycinate hydrochloride were suspended in CH2Cl2. At 0° C., 86.3 g (0.854 mol) of triethylamin and 50 g (0.22 mol) of 2-trifluoromethyl-4-fluorobenzoylchlorid dissolved in 250 ml of CH2Cl2 were successively added dropwise. After 48 h at RT, the solution was washed and dried, and the solvent was removed. This gave 62.2 g (97% of theory) of the title compound as a colorless solid.

1. additionwere successively added dropwise
2. washthe solution was washed
3. customdried
4. customthe solvent was removed