HCID 44407298, compound → HCID 67153148, compound

HRID 506498Notes

Reaction equation

HRID 506498 reaction equation
[C:1]([C:5]1[N:10]=[C:9]([N:11]2[CH2:16][CH2:15][N:14]([CH2:17]/[CH:18]=[C:19](\[CH3:32])/[CH2:20][N:21]3[C:30]4[C:25](=[CH:26][CH:27]=[CH:28][CH:29]=4)[CH2:24][CH2:23][C:22]3=[O:31])[CH2:13][CH2:12]2)[CH:8]=[C:7]([C:33]([F:36])([F:35])[F:34])[N:6]=1)([CH3:4])([CH3:3])[CH3:2]>CO.[Pd]>[C:1]([C:5]1[N:10]=[C:9]([N:11]2[CH2:12][CH2:13][N:14]([CH2:17][CH2:18][CH:19]([CH3:32])[CH2:20][N:21]3[C:30]4[C:25](=[CH:26][CH:27]=[CH:28][CH:29]=4)[CH2:24][CH2:23][C:22]3=[O:31])[CH2:15][CH2:16]2)[CH:8]=[C:7]([C:33]([F:35])([F:36])[F:34])[N:6]=1)([CH3:2])([CH3:3])[CH3:4]

Participants

4

Reactant 1

HCID 44407298HCID 44407298, compound

Product 1

HCID 67153148HCID 67153148, compoundYield 27.6%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

Pd/C (10%, 10.0 mg) was added to a solution of 1-((2E)-4-{4-[2-tert-butyl-6-(trifluoro-methyl)pyrimidin-4-yl]piperazin-1-yl}-2-methylbut-2-enyl)-3,4-dihydroquinolin-2(1H)-one (0.08 mmol, 49.99 mg) from example 12 in methanol (10 ml), and hydrogenation was then carried out at room temperature for 12 hours. 11.10 mg of the title compound were obtained.

Sources & evidence

ORD record
ord-16fe4709d9d548e2be8557ffbae725b3
Source dataset
uspto-grants-2010_08
Patent number
US07786105B2

Reaction notes

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