反应详情

温度

80 °C

To 20.7 g of benzyl 3-benzyloxy-2-nitrobenzoate were added 100 ml of ethanol and 120 ml of a 1N aqueous solution of sodium hydroxide and the mixture was stirred at room temperature for one night, at 60° C. for 3 hours and at 80° C. for 5 hours. After ethanol was evaporated in vacuo, the resulting aqueous solution was washed with ether and hydrochloric acid was added thereto. The resulting precipitate was collected by filtration and dried in vacuo to give 15.8 g of 3-benzyloxy-2-nitrobenzoic acid.

1. customAfter ethanol was evaporated in vacuo
2. washthe resulting aqueous solution was washed with ether and hydrochloric acid
3. additionwas added
4. filtrationThe resulting precipitate was collected by filtration
5. customdried in vacuo