Sodium Hydroxide → Benzoic acid, 2-nitro-3-(phenylmethoxy)-

HRID 506531Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 506531
[CH2:1]([O:8][C:9]1[C:10]([N+:25]([O-:27])=[O:26])=[C:11]([CH:22]=[CH:23][CH:24]=1)[C:12]([O:14]CC1C=CC=CC=1)=[O:13])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[OH-].[Na+]>C(O)C>[CH2:1]([O:8][C:9]1[C:10]([N+:25]([O-:27])=[O:26])=[C:11]([CH:22]=[CH:23][CH:24]=1)[C:12]([OH:14])=[O:13])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Komponenten

4

Edukt 2

HCID 14798Sodium HydroxideHCID 10594871Benzyl 3-benzyloxy-2-nitrobenzoate

Produkt 1

HCID 10802200Benzoic acid, 2-nitro-3-(phenylmethoxy)-Ausbeute 101,5 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Reaktionsbedingungen

Temperatur
80 °C

Versuchsvorschrift

To 20.7 g of benzyl 3-benzyloxy-2-nitrobenzoate were added 100 ml of ethanol and 120 ml of a 1N aqueous solution of sodium hydroxide and the mixture was stirred at room temperature for one night, at 60° C. for 3 hours and at 80° C. for 5 hours. After ethanol was evaporated in vacuo, the resulting aqueous solution was washed with ether and hydrochloric acid was added thereto. The resulting precipitate was collected by filtration and dried in vacuo to give 15.8 g of 3-benzyloxy-2-nitrobenzoic acid.

Aufarbeitung

  1. customAfter ethanol was evaporated in vacuo
  2. washthe resulting aqueous solution was washed with ether and hydrochloric acid
  3. additionwas added
  4. filtrationThe resulting precipitate was collected by filtration
  5. customdried in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-b93a6f917a2446db98b31bb2e776eff8
Quelldatensatz
uspto-grants-2010_08
Patentnummer
US07786106B2

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