Sodium Hydroxide → Benzoic acid, 2-nitro-3-(phenylmethoxy)-

Participants

Reaction Conditions

Reaction Steps

To 20.7 g of benzyl 3-benzyloxy-2-nitrobenzoate were added 100 ml of ethanol and 120 ml of a 1N aqueous solution of sodium hydroxide and the mixture was stirred at room temperature for one night, at 60° C. for 3 hours and at 80° C. for 5 hours. After ethanol was evaporated in vacuo, the resulting aqueous solution was washed with ether and hydrochloric acid was added thereto. The resulting precipitate was collected by filtration and dried in vacuo to give 15.8 g of 3-benzyloxy-2-nitrobenzoic acid.

Provenance & Evidence