反应详情

A solution of 1.00 g (1.73 mmol) of ethyl 4-(4-{2-[2-(6-benzyloxy-3-oxo-3,4-dihydro-2H-benzo[1,4]oxazin-8-yl)-2-hydroxyethylamino]-2-methylpropyl}phenoxy)butyrate in 25 mL methanol is combined with 2.5 mL of 1 N sodium hydroxide solution, refluxed for 30 minutes, and then neutralized with 1 N hydrochloric acid. The solution is evaporated down and the residual oil is dissolved by heating in 5 mL of n-butanol. After the addition of a crystallization aid, a solid is precipitated out which is suction filtered and washed with acetone and diethyl ether. Yield: 0.75 g (79%); melting point: 216° C.-218° C.

1. temperaturerefluxed for 30 minutes
2. customThe solution is evaporated down
3. dissolutionthe residual oil is dissolved
4. temperatureby heating in 5 mL of n-butanol
5. additionAfter the addition of a crystallization aid
6. customa solid is precipitated out which
7. filtrationfiltered
8. washwashed with acetone and diethyl ether