Acetyl chloride → HCID 178474132, compound

HRID 506592Notes

Reaction equation

HRID 506592 reaction equation
[CH:1]([O:4][C:5](=[O:23])[NH:6][C:7]1[CH:8]=[C:9]2[N:15]=[C:14]([C:16]3[CH:21]=[CH:20][CH:19]=[C:18]([NH2:22])[CH:17]=3)[NH:13][C:10]2=[N:11][CH:12]=1)([CH3:3])[CH3:2].[C:24](Cl)(=[O:26])[CH3:25]>N1C=CC=CC=1>[CH:1]([O:4][C:5](=[O:23])[NH:6][C:7]1[CH:8]=[C:9]2[N:15]=[C:14]([C:16]3[CH:21]=[CH:20][CH:19]=[C:18]([NH:22][C:24](=[O:26])[CH3:25])[CH:17]=3)[NH:13][C:10]2=[N:11][CH:12]=1)([CH3:3])[CH3:2]

Participants

4

Reactant 2

HCID 6367Acetyl chlorideHCID 178459834HCID 178459834, compound

Product 1

HCID 178474132HCID 178474132, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

10 mg of the product from example 5-1 were dissolved in 1 ml dry pyridine and 7 μl acetyl chloride were added at room temperature. After stirring over night, the solvent was evaporated and the residue dissolved in 3 ml methanol. 1 ml conc. ammonia were added and the mixture stirred for 1 hr at room temperature.

Workup

  1. customthe solvent was evaporated
  2. dissolutionthe residue dissolved in 3 ml methanol
  3. addition1 ml conc. ammonia were added
  4. stirringthe mixture stirred for 1 hr at room temperature

Sources & evidence

ORD record
ord-056109d4d495401cbc49f8702a65f332
Source dataset
uspto-grants-2010_08
Patent number
US07786113B2

Reaction notes

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