[4-(4-Methylpiperazin-1-yl)phenyl]methanamine → HCID 68469454, compound

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Reaction Steps

The product is prepared by following the procedure described in example 34, stage (j), starting with 0.1 g of 2-(5,6-dimethoxy-1-methyl-1H-pyrrolo[3,2-b]pyridin-3-yl)-1-(toluene-4-sulfonyl)-1H-pyrrolo[2,3-b]pyridin-4-carbaldehyde and 0.209 cm3 of 4-(4-methylpiperazino)benzylamine instead of the cyclopropylamine used in example 34, stage (j). After purification by flash-pack chromatography (SiO2, dichloromethane/methanol 90/10 by volume as eluents), 0.083 g of [2-(5,6-dimethoxy-1-methyl-1H-pyrrolo[3,2-b]pyridin-3-yl)-1-(toluene-4-sulfonyl)-1H-pyrrolo[2,3-b]pyridin-4-ylmethyl]-[4-(4-methylpiperazin-1-yl)-benzyl]amine is obtained with the following characteristics:

Provenance & Evidence