Hydrochloric Acid → HCID 68466854, compound

HRID 506827Notes

Reaction equation

HRID 506827 reaction equation
[CH3:1][O:2][C:3]1[N:8]=[C:7]2[C:9]([C:13]3[NH:34][C:16]4=[N:17][CH:18]=[CH:19][C:20]([CH2:21][NH:22][CH:23]5[CH2:26][N:25](C(OC(C)(C)C)=O)[CH2:24]5)=[C:15]4[CH:14]=3)=[CH:10][N:11]([CH3:12])[C:6]2=[CH:5][C:4]=1[O:35][CH3:36].[ClH:37]>O1CCOCC1>[ClH:37].[NH:25]1[CH2:26][CH:23]([NH:22][CH2:21][C:20]2[CH:19]=[CH:18][N:17]=[C:16]3[NH:34][C:13]([C:9]4[C:7]5=[N:8][C:3]([O:2][CH3:1])=[C:4]([O:35][CH3:36])[CH:5]=[C:6]5[N:11]([CH3:12])[CH:10]=4)=[CH:14][C:15]=23)[CH2:24]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 68468330HCID 68468330, compound

Product 1

HCID 68466854HCID 68466854, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

The product is prepared by following the procedure described in example 51, starting with 0.075 g of tert-butyl 3-{[2-(5,6-dimethoxy-1-methyl-1H-pyrrolo[3,2-b]pyridin-3-yl)-1H-pyrrolo[2,3-b]pyridin-4-ylmethyl]amino}azetidine-1-carboxylate instead of the tert-butyl (2-{[2-(5,6-dimethoxy-1-methyl-1H-pyrrolo[3,2-b]pyridin-3-yl)-1H-pyrrolo[2,3-b]pyridin-4-ylmethyl]amino}ethyl)carbamate used in example 51 and 1.2 cm3 of 5N hydrochloric acid in dioxane. 0.077 g of azetidin-3-yl-[2-(5,6-dimethoxy-1-methyl-1H-pyrrolo[3,2-b]pyridin-3-yl)-1H-pyrrolo[2,3-b]pyridin-4-ylmethyl]amine hydrochloride is obtained with the following characteristics:

Workup

  1. customThe product is prepared

Sources & evidence

ORD record
ord-45789704db9d4dc3a5dfcf1522f6c2b1
Source dataset
uspto-grants-2010_08
Patent number
US07786114B2

Reaction notes

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