Potassium Hydroxide → HCID 68470556, compound

HRID 506833Notes

Reaction equation

[CH3:1][O:2][C:3]1[N:8]=[C:7]2[C:9]([C:13]3[N:28](S(C4C=CC(C)=CC=4)(=O)=O)[C:16]4=[N:17][CH:18]=[CH:19][C:20]([CH2:21][S:22][C:23]5[S:24][CH:25]=[CH:26][CH:27]=5)=[C:15]4[CH:14]=3)=[CH:10][N:11]([CH3:12])[C:6]2=[CH:5][C:4]=1[O:39][CH3:40].[OH-].[K+]>>[CH3:1][O:2][C:3]1[N:8]=[C:7]2[C:9]([C:13]3[NH:28][C:16]4=[N:17][CH:18]=[CH:19][C:20]([CH2:21][S:22][C:23]5[S:24][CH:25]=[CH:26][CH:27]=5)=[C:15]4[CH:14]=3)=[CH:10][N:11]([CH3:12])[C:6]2=[CH:5][C:4]=1[O:39][CH3:40]

Participants

Reactant 2

HCID 14797Potassium Hydroxide

HCID 68468046HCID 68468046, compound

Product 1

HCID 68470556HCID 68470556, compoundYield 98.4%

Procedure

The product is prepared by following the procedure described in example 34 stage (k), starting with 0.110 g of 5,6-dimethoxy-1-methyl-3-[4-(thiophen-2-ylsulfanylmethyl)-1-(toluene-4-sulfonyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-1H-pyrrolo[3,2-b]pyridine instead of the cyclopropyl-[2-(5,6-dimethoxy-1-methyl-1H-pyrrolo[3,2-b]pyridin-3-yl)-1-(toluene-4-sulfonyl)-1H-pyrrolo[2,3-b]pyridin-4-ylmethyl]amine used in example 34 stage (k) and 0.8 cm3 of 5N potassium hydroxide. 0.080 g of 5,6-dimethoxy-1-methyl-3-[4-(thiophen-2-ylsulfanylmethyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-1H-pyrrolo[3,2-b]pyridine is obtained with the following characteristics:

Workup

customThe product is prepared

Sources & evidence

ORD record: ord-c1a961513c4a40d2a5e7d8bcb28fa34d
Source dataset: uspto-grants-2010_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07786114B2

Reaction notes

Loading…