HRID506842

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：COc1cccc(C2C(CCC(O[Si](C)(C)C(C)(C)C)c3ccccc3)C(=O)N2c2ccc([N+](=O)[O-])cc2)c1

HCID68639713

未命名化合物

HCID178418361

未命名化合物

PRODUCTS

生成物

结构：COc1cccc(C2C(CCC(O[Si](C)(C)C(C)(C)C)c3ccccc3)C(=O)N2c2ccc(N)cc2)c1

HCID68640069

未命名化合物

收率 86%

AUXILIARIES

试剂、催化剂与溶剂

催化剂HCID23938

Palladium

溶剂HCID8857

Ethyl acetate

C4H8O2

PROCEDURE

实验过程

A reaction is performed with 3.0 g (5.5 mmol) of product 4 in 50 ml ethylacetate and 1.0 g of palladium charcoal 10% for 2 h at 5 bar of a hydrogen atmosphere using an autoclave. The reaction solution is filtrated, evaporated and separated by chromatography on silica gel (methylenehloride/methanol=10/1). 2.4 g (86%) of product 5 is obtained in form of a colourless compound in solid form: C31H40N2O3Si (516.76) MS (ESI+) 517.4 (M+H+).

WORKUP

后处理

filtrationThe reaction solution is filtrated
customevaporated
customseparated by chromatography on silica gel (methylenehloride/methanol=10/1)

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-d3ec46ba7c144d1397e9c8f9da063ee7
来源数据集: uspto-grants-2010_08
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07786103B2
来源说明: uspto-grants-2010_08

反应 SMILES

[C:1]([Si:5]([CH3:39])([CH3:38])[O:6][CH:7]([C:32]1[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=1)[CH2:8][CH2:9][CH:10]1[CH:13]([C:14]2[CH:19]=[CH:18][CH:17]=[C:16]([O:20][CH3:21])[CH:15]=2)[N:12]([C:22]2[CH:27]=[CH:26][C:25]([N+:28]([O-])=O)=[CH:24][CH:23]=2)[C:11]1=[O:31])([CH3:4])([CH3:3])[CH3:2].[H][H]>C(OC(=O)C)C.[Pd]>[NH2:28][C:25]1[CH:26]=[CH:27][C:22]([N:12]2[CH:13]([C:14]3[CH:19]=[CH:18][CH:17]=[C:16]([O:20][CH3:21])[CH:15]=3)[CH:10]([CH2:9][CH2:8][CH:7]([O:6][Si:5]([C:1]([CH3:3])([CH3:2])[CH3:4])([CH3:38])[CH3:39])[C:32]3[CH:33]=[CH:34][CH:35]=[CH:36][CH:37]=3)[C:11]2=[O:31])=[CH:23][CH:24]=1