HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → HCID 68639813, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Sodium Bicarbonate | HCID 516892 | — |
| Reactant | 1-(4-Amino-phenyl)-3-[3-(tert-butyl-dimethyl-silanyloxy)-3-phenyl-propyl]-4-(3-methoxy-phenyl)-azetidin-2-on | HCID 68640069 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 68639813 | HCID 68639813 | 61.4% |
Reaction Steps
15 ml of 2N aqueous hydrochloric acid are added to 2.3 g of product 5 in 20 ml of tetrahydrofuran and stirred for 2 h. An aqueous solution of sodium hydrogencarbonate is added to the reaction and extracted by ethylacetate. The organic phase is dried by magnesium sulfate, evaporated and purified by chromatography on silica gel (ethylacetate/heptane=1/1->1/0). 1.1 g of product 6 is obtained in form of a colorless compound in solid form: C25H26N2O3 (402.50) MS (ESI+) 403.2 (M+H+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07786103B2 |
| Source dataset | uspto-grants-2010_08 |
| ORD ID | ord-f0456610e91b421a91e46f79294de2d0 |
| Source note | uspto-grants-2010_08 |