Eltoprazine → 3-{4-[4-(2,3-Dihydrobenzo[1,4]dioxin-5-yl)-piperazin-1-yl]-butyl}-3-ethyl-6-fluoro-1,3-dihydro-2H-indol-2-one

HRID 506914Notes

Reaction equation

HRID 506914 reaction equation
Cl[CH2:2][CH2:3][CH2:4][CH2:5][C:6]1([CH2:17][CH3:18])[C:14]2[C:9](=[CH:10][C:11]([F:15])=[CH:12][CH:13]=2)[NH:8][C:7]1=[O:16].[O:19]1[C:24]2[CH:25]=[CH:26][CH:27]=[C:28]([N:29]3[CH2:34][CH2:33][NH:32][CH2:31][CH2:30]3)[C:23]=2[O:22][CH2:21][CH2:20]1>>[O:19]1[C:24]2[CH:25]=[CH:26][CH:27]=[C:28]([N:29]3[CH2:34][CH2:33][N:32]([CH2:2][CH2:3][CH2:4][CH2:5][C:6]4([CH2:17][CH3:18])[C:14]5[C:9](=[CH:10][C:11]([F:15])=[CH:12][CH:13]=5)[NH:8][C:7]4=[O:16])[CH2:31][CH2:30]3)[C:23]=2[O:22][CH2:21][CH2:20]1

Participants

3

Reactant 2

HCID 65853EltoprazineHCID 684636233-(4-Chlorobutyl)-3-ethyl-6-fluoro-1,3-dihydro-2H-indol-2-one

Product 1

HCID 684672513-{4-[4-(2,3-Dihydrobenzo[1,4]dioxin-5-yl)-piperazin-1-yl]-butyl}-3-ethyl-6-fluoro-1,3-dihydro-2H-indol-2-one

Procedure

The title compound is prepared according to process H by applying processing method 1 starting from 3-(4-chlorobutyl)-3-ethyl-6-fluoro-1,3-dihydro-2H-indol-2-one and 4-(2,3-dihydro-benzo[1,4]dioxin-5-yl)-piperazine.

Sources & evidence

ORD record
ord-d7d3e10705034d2cac4da829d7520a56
Source dataset
uspto-grants-2010_08
Patent number
US07786129B2

Reaction notes

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