1-(4-Chloro-3-(trifluoromethyl)phenyl)piperazine → 3-{4-[4-(4-Chloro-3-trifluoromethyl-phenyl)-piperazin-1-yl]-butyl}-3-ethyl-1,3-dihydro-2h-indol-2-one monohydrochloride

HRID 506924Notes

Reaction equation

HRID 506924 reaction equation
[Cl:1][CH2:2][CH2:3][CH2:4][CH2:5][C:6]1([CH2:16][CH3:17])[C:14]2[C:9](=[CH:10][CH:11]=[CH:12][CH:13]=2)[NH:8][C:7]1=[O:15].[Cl:18][C:19]1[CH:24]=[CH:23][C:22]([N:25]2[CH2:30][CH2:29][NH:28][CH2:27][CH2:26]2)=[CH:21][C:20]=1[C:31]([F:34])([F:33])[F:32]>>[ClH:1].[Cl:18][C:19]1[CH:24]=[CH:23][C:22]([N:25]2[CH2:30][CH2:29][N:28]([CH2:2][CH2:3][CH2:4][CH2:5][C:6]3([CH2:16][CH3:17])[C:14]4[C:9](=[CH:10][CH:11]=[CH:12][CH:13]=4)[NH:8][C:7]3=[O:15])[CH2:27][CH2:26]2)=[CH:21][C:20]=1[C:31]([F:33])([F:32])[F:34]

Participants

3

Reactant 2

HCID 27781371-(4-Chloro-3-(trifluoromethyl)phenyl)piperazineHCID 670406333-(4-Chlorobutyl)-3-ethyl-1,3-dihydro-2H-indol-2-one

Product 1

HCID 684681913-{4-[4-(4-Chloro-3-trifluoromethyl-phenyl)-piperazin-1-yl]-butyl}-3-ethyl-1,3-dihydro-2h-indol-2-one monohydrochloride

Procedure

The title compound is prepared according to process H by applying processing method 2 starting from 3-(4-chlorobutyl)-3-ethyl-1,3-dihydro-2H-indol-2-one and 1-(4-chloro-3-tri-fluormethyl-phenyl)-piperazine.

Sources & evidence

ORD record
ord-7a48f56c5dbc4e4e9d9a6b7855a66f5c
Source dataset
uspto-grants-2010_08
Patent number
US07786129B2

Reaction notes

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