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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 506924Generated: November 4, 2026

1-(4-Chloro-3-(trifluoromethyl)phenyl)piperazine → 3-{4-[4-(4-Chloro-3-trifluoromethyl-phenyl)-piperazin-1-yl]-butyl}-3-ethyl-1,3-dihydro-2h-indol-2-one monohydrochloride

https://huagongshe.com/reaction/506924

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1-(4-Chloro-3-(trifluoromethyl)phenyl)piperazineHCID 2778137—
Reactant3-(4-Chlorobutyl)-3-ethyl-1,3-dihydro-2H-indol-2-oneHCID 67040633—
Product3-{4-[4-(4-Chloro-3-trifluoromethyl-phenyl)-piperazin-1-yl]-butyl}-3-ethyl-1,3-dihydro-2h-indol-2-one monohydrochlorideHCID 68468191—

Reaction Steps

The title compound is prepared according to process H by applying processing method 2 starting from 3-(4-chlorobutyl)-3-ethyl-1,3-dihydro-2H-indol-2-one and 1-(4-chloro-3-tri-fluormethyl-phenyl)-piperazine.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07786129B2
Source datasetuspto-grants-2010_08
ORD IDord-7a48f56c5dbc4e4e9d9a6b7855a66f5c
Source noteuspto-grants-2010_08