3-Chloro-4-fluorophenylpiperazine → 3-{4-[4-(3-chloro-4-fluorophenyl)-piperazin-1-yl]-butyl}-3-ethyl-6-fluoro-1,3-dihydro-2H-indol-2-one monohydrochloride

HRID 506942Notes

Reaction equation

HRID 506942 reaction equation
[Cl:1][CH2:2][CH2:3][CH2:4][CH2:5][C:6]1([CH2:17][CH3:18])[C:14]2[C:9](=[CH:10][C:11]([F:15])=[CH:12][CH:13]=2)[NH:8][C:7]1=[O:16].[Cl:19][C:20]1[CH:21]=[C:22]([N:27]2[CH2:32][CH2:31][NH:30][CH2:29][CH2:28]2)[CH:23]=[CH:24][C:25]=1[F:26]>>[ClH:1].[Cl:19][C:20]1[CH:21]=[C:22]([N:27]2[CH2:32][CH2:31][N:30]([CH2:2][CH2:3][CH2:4][CH2:5][C:6]3([CH2:17][CH3:18])[C:14]4[C:9](=[CH:10][C:11]([F:15])=[CH:12][CH:13]=4)[NH:8][C:7]3=[O:16])[CH2:29][CH2:28]2)[CH:23]=[CH:24][C:25]=1[F:26]

Participants

3

Reactant 2

HCID 27792633-Chloro-4-fluorophenylpiperazineHCID 684636233-(4-Chlorobutyl)-3-ethyl-6-fluoro-1,3-dihydro-2H-indol-2-one

Product 1

HCID 684656913-{4-[4-(3-chloro-4-fluorophenyl)-piperazin-1-yl]-butyl}-3-ethyl-6-fluoro-1,3-dihydro-2H-indol-2-one monohydrochloride

Procedure

The title compound is prepared according to process H by applying processing method 2 from 3-(4-chlorobutyl)-3-ethyl-6-fluoro-1,3-dihydro-2H-indol-2-one and 1-(3-chloro-4-fluorophenyl)-piperazine.

Sources & evidence

ORD record
ord-1d3aff0aa4f74032bb232d4e71ee78a2
Source dataset
uspto-grants-2010_08
Patent number
US07786129B2

Reaction notes

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