Methanol → methyl 3-[7-[3-(dimethylamino)propyl]-1-oxoisoquinolin-2(1H)-yl]-4-methylbenzoate

HRID 506994Notes

Reaction equation

HRID 506994 reaction equation
[CH3:1][N:2]([CH3:28])[CH2:3][C:4]#[C:5][C:6]1[CH:15]=[C:14]2[C:9]([CH:10]=[CH:11][N:12]([C:17]3[CH:18]=[C:19]([CH:24]=[CH:25][C:26]=3[CH3:27])[C:20]([O:22][CH3:23])=[O:21])[C:13]2=[O:16])=[CH:8][CH:7]=1.CO.C(OCC)(=O)C>C(O)C.[Pd]>[CH3:28][N:2]([CH3:1])[CH2:3][CH2:4][CH2:5][C:6]1[CH:15]=[C:14]2[C:9]([CH:10]=[CH:11][N:12]([C:17]3[CH:18]=[C:19]([CH:24]=[CH:25][C:26]=3[CH3:27])[C:20]([O:22][CH3:23])=[O:21])[C:13]2=[O:16])=[CH:8][CH:7]=1

Participants

6

Reactant 3

HCID 887MethanolHCID 8857Ethyl AcetateHCID 67018594methyl 3-[7-[3-(dimethylamino)prop-1-yn-1-yl]-1-oxoisoquinolin-2(1H)-yl]-4-methylbenzoate

Product 1

HCID 67018581methyl 3-[7-[3-(dimethylamino)propyl]-1-oxoisoquinolin-2(1H)-yl]-4-methylbenzoate

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

Methyl 3-[7-[3-(dimethylamino)prop-1-yn-1-yl]-1-oxoisoquinolin-2(1H)-yl]-4-methylbenzoate (192 mg) and 10% Pd/C (20 mg) were stirred in a mixture of ethanol (2 ml)/methanol (4 ml)/ethyl acetate (1 ml) under an atmosphere of hydrogen at room temperature for 2 hours. The catalyst was removed by filtration through a microfibre filter and the filtrate was concentrated to yield an oil. The oil was purified by column chromatography on an ion exchange column (isolute SCX column from International Sorbent Technology Limited, Henoed, Mid-Glamorgan, UK) using initially methanol and then a 99:1 mixture of methanol and aqueous ammonia solution to yield methyl 3-[7-[3-(dimethylamino)propyl]-1-oxoisoquinolin-2(1H)-yl]-4-methylbenzoate as a yellow oil that turned to a pale yellow solid on standing (155 mg); NMR Spectrum: (DMSOd6) 1.76 (m, 2H), 2.14 (s, 6H), 2.15 (s, 3H), 2.23 (t, 2H), 2.76 (t, 2H), 3.87 (s, 3H), 6.72 (d, 1H), 7.30 (d, 1H), 7.59 (d, 1H), 7.67 (m, 2H), 7.83 (s, 1H), 7.98 (d, 1H), 8.07 (s, 1H); Mass Spectrum: M+H+ 379.

Workup

  1. customThe catalyst was removed by filtration through
  2. filtrationa microfibre filter
  3. concentrationthe filtrate was concentrated
  4. customto yield an oil
  5. customThe oil was purified by column chromatography on an ion exchange column (isolute SCX column from International Sorbent Technology Limited, Henoed, Mid-Glamorgan, UK)
  6. additiona 99:1 mixture of methanol and aqueous ammonia solution

Sources & evidence

ORD record
ord-abe1f3b59d964669a77c0cd591a26284
Source dataset
uspto-grants-2010_08
Patent number
US07786115B2

Reaction notes

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