HCID 59432345, compound → HCID 11548876, compound

HRID 507047Notes

Reaction equation

HRID 507047 reaction equation
C([O:8][CH2:9][CH2:10][N:11]1[CH2:17][CH2:16][CH2:15][C@H:14]([N:18]([CH2:25][C:26]2[CH:31]=[C:30]([C:32]([F:35])([F:34])[F:33])[CH:29]=[C:28]([C:36]([F:39])([F:38])[F:37])[CH:27]=2)[C:19]2[N:20]=[N:21][N:22]([CH3:24])[N:23]=2)[C:13]2[CH:40]=[C:41]([CH3:48])[C:42]([C:44]([F:47])([F:46])[F:45])=[CH:43][C:12]1=2)C1C=CC=CC=1>[Pd].C(O)C>[F:34][C:32]([F:33])([F:35])[C:30]1[CH:31]=[C:26]([CH:27]=[C:28]([C:36]([F:39])([F:38])[F:37])[CH:29]=1)[CH2:25][N:18]([C:19]1[N:20]=[N:21][N:22]([CH3:24])[N:23]=1)[C@H:14]1[CH2:15][CH2:16][CH2:17][N:11]([CH2:10][CH2:9][OH:8])[C:12]2[CH:43]=[C:42]([C:44]([F:45])([F:46])[F:47])[C:41]([CH3:48])=[CH:40][C:13]1=2

Participants

4

Reactant 1

HCID 59432345HCID 59432345, compound

Product 1

HCID 11548876HCID 11548876, compoundYield 97%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

Stir a mixture of (S)-[1-(2-Benzyloxy-ethyl)-7-methyl-8-trifluoromethyl-2,3,4,5-tetrahydro-1H-benzo[b]azepin-5-yl]-(3,5-bis-trifluoromethyl-benzyl)-(2-methyl-2H-tetrazol-5-yl)-amine (0.420 g, 0.612 mmol) and 10% palladium on charcoal (0.210 g) in ethanol (50 mL) under a hydrogen balloon at room temperature for 3 h. Filter the mixture through Celite® and remove the solvents under reduced pressure to provide the title compound as a colorless foam (0.350 g, 97%). MS (ES+): 597 (M+H).

Workup

  1. filtrationFilter the mixture through Celite®
  2. customremove the solvents under reduced pressure

Sources & evidence

ORD record
ord-32679f04de2246d9b5aa9e3bd18ff38e
Source dataset
uspto-grants-2010_08
Patent number
US07786108B2

Reaction notes

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