反应详情

Add hydroxylamine hydrochloride (39 mg, 0.55 mmol) and sodium acetate (1.5 mg, 0.018 mmol). to a solution of compound (+/−)-5-[(3,5-bistrifluoromethyl-benzyl)-(3-oxo-butyryl)-amino]-8-chloro-2,3,4,5-tetrahydrobenzo[b]azepine-1-carboxylic acid isopropyl ester (Example 51, Step 1) (218 mg, 0.37 mmol) in methanol (1.8 mL) at 0° C., Heat the reaction mixture under reflux overnight. Cool and remove the solvents under reduce pressure. Dilute the residue with ethyl acetate and brine. Separate the layers and dry the organic phase over magnesium sulfate, filter and concentrate in vacuo. Purify the residue by flash chromatography, eluting with hexanes/ethyl acetate to afford the title compound (85 mg, 39%). MS (ES+): 590 (M+H).

1. temperatureunder reflux overnight
2. temperatureCool
3. customremove the solvents
4. additionDilute the residue with ethyl acetate and brine
5. customSeparate the layers
6. dry with materialdry the organic phase over magnesium sulfate
7. filtrationfilter
8. concentrationconcentrate in vacuo
9. customPurify the residue by flash chromatography
10. washeluting with hexanes/ethyl acetate