Hydrochloric Acid → HCID 11592750, compound

HRID 507140Notes

Reaction equation

HRID 507140 reaction equation
[ClH:1].[NH2:2][CH2:3][CH2:4][N:5]1[N:9]=[N:8][C:7]([N:10]([CH2:31][C:32]2[CH:37]=[C:36]([C:38]([F:41])([F:40])[F:39])[CH:35]=[C:34]([C:42]([F:45])([F:44])[F:43])[CH:33]=2)[C@H:11]2[CH2:17][CH2:16][CH2:15][N:14]([CH2:18][CH:19]3[CH2:21][CH2:20]3)[C:13]3[CH:22]=[C:23]([C:27]([F:30])([F:29])[F:28])[C:24]([CH3:26])=[CH:25][C:12]2=3)=[N:6]1>C(OCC)C>[ClH:1].[NH2:2][CH2:3][CH2:4][N:5]1[N:9]=[N:8][C:7]([N:10]([CH2:31][C:32]2[CH:33]=[C:34]([C:42]([F:43])([F:44])[F:45])[CH:35]=[C:36]([C:38]([F:41])([F:40])[F:39])[CH:37]=2)[C@H:11]2[CH2:17][CH2:16][CH2:15][N:14]([CH2:18][CH:19]3[CH2:21][CH2:20]3)[C:13]3[CH:22]=[C:23]([C:27]([F:29])([F:30])[F:28])[C:24]([CH3:26])=[CH:25][C:12]2=3)=[N:6]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 11592751HCID 11592751, compound

Product 1

HCID 11592750HCID 11592750, compound

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent2×

Procedure

Add 1.0 N HCl in ethyl ether (0.0500 mL) to a solution of (S)-[2-(2-Amino-ethyl)-2H-tetrazol-5-yl]-(3,5-bis-trifluoromethyl-benzyl)-(1-cyclopropylmethyl-7-methyl-8-trifluoromethyl-2,3,4,5-tetrahydro-1H-benzo[b]azepin-5-yl)-amine (0.0300 mg, 0.0472 mmole) in ethyl ether (0.500 mL), stir for 10 minutes. Evaporate the solvent to provide the title compound as white powder. MS (ES+): 636 (M+H).

Workup

  1. customEvaporate the solvent

Sources & evidence

ORD record
ord-8548898515f54098a530fb2b98d2c4a9
Source dataset
uspto-grants-2010_08
Patent number
US07786108B2

Reaction notes

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