HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Hydroxide → 2-Phenoxymethyl-1-(4-trifluoromethylsulfanyl-benzyl)-1H-indole-5-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | 2-Phenoxymethyl-1-(4-trifluoromethylsulfanyl-benzyl)-1H-indole-5-carboxylic acid methyl ester | HCID 68463737 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | 2-Phenoxymethyl-1-(4-trifluoromethylsulfanyl-benzyl)-1H-indole-5-carboxylic acid | HCID 68465701 | — |
Reaction Steps
2-Phenoxymethyl-1-(4-trifluoromethylsulfanyl-benzyl)-1H-indole-5-carboxylic acid methyl ester was dissolved in dioxane and treated with 1M NaOH at 50° C. for 16 h. The solvents were evaporated and the remaining solid treated with 0.5 ml HCl/1 ml ethylacetate and extracted with water.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07786128B2 |
| Source dataset | uspto-grants-2010_08 |
| ORD ID | ord-23b2a7dc379242c59c64c218b0c30303 |
| Source note | uspto-grants-2010_08 |