反应详情

温度

200 °C

A flask is charged with 5-bromo-dimethyltryptamin (5.34 g, 20 mmol), copper (I)cyanide (2.69 g, 30 mmol), and N-Methylpyrrolidone (20 ml). The mixture is heated at 200° C. for 9 hours under a nitrogen atmosphere and then left stirring over night. The brown mixture is poured on water to give a brown precipitate. This is suspended in ammonia (100 ml 25% solution in water), and the mixture is stirred over night. Extraction with TBME (3*100 ml), and removal of the solvent from the dried (sodium sulfate) organic layer gives the title product as a yellow solid (properties as in Reference Example 3).

1. waitleft
2. additionThe brown mixture is poured on water
3. customto give a brown precipitate
4. stirringthe mixture is stirred over night
5. extractionExtraction
6. customwith TBME (3*100 ml), and removal of the solvent from the
7. dry with materialdried (sodium sulfate) organic layer