Acetyl chloride → HCID 59434032, compound

HRID 507394Notes

Reaction equation

HRID 507394 reaction equation
[NH2:1][CH2:2][CH2:3][N:4]([CH2:14][C:15]([N:17]1[CH2:21][C:20](=[O:22])[N:19]([C:23]2[CH:28]=[CH:27][CH:26]=[C:25]([Cl:29])[C:24]=2[CH3:30])[CH2:18]1)=[O:16])[C:5](=[O:13])[C:6]1[CH:11]=[CH:10][CH:9]=[C:8]([Cl:12])[CH:7]=1.[C:31](Cl)(=[O:33])[CH3:32]>C1COCC1>[C:31]([NH:1][CH2:2][CH2:3][N:4]([CH2:14][C:15]([N:17]1[CH2:21][C:20](=[O:22])[N:19]([C:23]2[CH:28]=[CH:27][CH:26]=[C:25]([Cl:29])[C:24]=2[CH3:30])[CH2:18]1)=[O:16])[C:5](=[O:13])[C:6]1[CH:11]=[CH:10][CH:9]=[C:8]([Cl:12])[CH:7]=1)(=[O:33])[CH3:32]

Participants

4

Reactant 2

HCID 6367Acetyl chlorideHCID 59434015HCID 59434015, compound

Product 1

HCID 59434032HCID 59434032, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

A mixture of N-(2-Amino-ethyl)-3-chloro-N-{2-[3-(3-chloro-2-methyl-phenyl)-4-oxo-imidazolidin-1-yl]-2-oxo-ethyl}-benzamide (80 mg, 0.16 mmol, 1 eq), Acetyl chloride (0.014 ml, 0.19 mmol, 1.2 eq), TEA (0.07 ml) in THF (1 ml) was stirred at room temperature overnight. It was purified with HPLC to give the desired product. LCMS observed for (M+H)+: 491.2

Workup

  1. customIt was purified with HPLC

Sources & evidence

ORD record
ord-93b133975206413e9bd796c26497f255
Source dataset
uspto-grants-2010_08
Patent number
US07786157B2

Reaction notes

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