Methanesulfonyl chloride → HCID 59434040, compound

HRID 507396Notes

Reaction equation

HRID 507396 reaction equation
[NH2:1][CH2:2][CH2:3][N:4]([CH2:14][C:15]([N:17]1[CH2:21][C:20](=[O:22])[N:19]([C:23]2[CH:28]=[CH:27][CH:26]=[C:25]([Cl:29])[C:24]=2[CH3:30])[CH2:18]1)=[O:16])[C:5](=[O:13])[C:6]1[CH:11]=[CH:10][CH:9]=[C:8]([Cl:12])[CH:7]=1.[CH3:31][S:32](Cl)(=[O:34])=[O:33]>C1COCC1>[Cl:12][C:8]1[CH:7]=[C:6]([CH:11]=[CH:10][CH:9]=1)[C:5]([N:4]([CH2:14][C:15]([N:17]1[CH2:21][C:20](=[O:22])[N:19]([C:23]2[CH:28]=[CH:27][CH:26]=[C:25]([Cl:29])[C:24]=2[CH3:30])[CH2:18]1)=[O:16])[CH2:3][CH2:2][NH:1][S:32]([CH3:31])(=[O:34])=[O:33])=[O:13]

Participants

4

Reactant 2

HCID 31297Methanesulfonyl chlorideHCID 59434015HCID 59434015, compound

Product 1

HCID 59434040HCID 59434040, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

A mixture of N-(2-Amino-ethyl)-3-chloro-N-{2-[3-(3-chloro-2-methyl-phenyl)-4-oxo-imidazolidin-1-yl]-2-oxo-ethyl}-benzamide (80 mg, 0.16 mmol, 1 eq), methanesulfonyl chloride (0.015 ml, 0.19 mmol, 1.2 eq), TEA (0.07 ml) in THF (1 ml) was stirred at room temperature overnight. It was purified with HPLC to give the desired product. LCMS observed for (M+H)+: 527.2

Workup

  1. customIt was purified with HPLC

Sources & evidence

ORD record
ord-e05c6c8a1df64a168864d457e1df8a1f
Source dataset
uspto-grants-2010_08
Patent number
US07786157B2

Reaction notes

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