反应详情

温度

70 °C

(+/−)-2-Methyl-5-phenyl-5-propyl-3,5-dihydro-imidazol-4-one (541 mg, 2.5 mmol) and 2-bromo-1-(4-nitro-phenyl)-ethanone (707 mg, 2.8 mmol) and potassium carbonate (698 mg, 5 mmol) are dissolved in 5 mL acetone and the reaction mixture is heated at 70° C. for 10 min in the microwave oven (Biotage Initiator). The mixture is cooled to room temperature filtered and the filtrate evaporated. The residue is subjected to flash chromatography (cyclohexane/ethyl acetate-gradient, ethyl acetate 0-100% in 20 min) to yield (+/−)-2-methyl-3-[2-(4-nitro-phenyl)-2-oxo-ethyl]-5-phenyl-5-propyl-3,5-dihydro-imidazol-4-one (528 mg, 56%). LC/MS at 254 nm; [M+H] 380; Rt 2.959 min.

1. temperatureThe mixture is cooled to room temperature
2. filtrationfiltered
3. customthe filtrate evaporated
4. customis subjected to flash chromatography (cyclohexane/ethyl acetate-gradient, ethyl acetate 0-100% in 20 min)