反应详情

Burgess reagent (0.8 g, 3.3 mmol) was added in portions to a solution of 5 (0.5 g, 1.58 mmol) in dry THF (20 mL) at room temperature, and was stirred overnight. The mixture was washed with water (20 mL), dried over Na2SO4, concentrated and purified by column chromatography on silica gel to produce compound 6 (0.2 g, 50%) 1H NMR (400 MHz, CDCl3) δ1.44 (s, 9 H), 2.08-2.11 (m, 1 H), 3.17-3.21 (m, 1H), 3.68 (d, 2 H), 4.50-4.60 (m, 1 H), 5.07 (s, 1 H), 5.14 (t, 1 H), 5.37 (t, 1 H).

1. washThe mixture was washed with water (20 mL)
2. dry with materialdried over Na2SO4
3. concentrationconcentrated
4. custompurified by column chromatography on silica gel