反应详情

To an ice cold solution of 0.158 g of 7-amino-4-(3-bromoanilino)-quinazoline (J Med Chem, 1985:3482) in 5 mL of tetrahydrofuran was added dropwise a solution of 0.105 g of crotonic acid chloride in 5 mL of tetrahydrofuran. When the addition was complete, the ice bath was removed and the reaction stirred at room temperature for 15 hours. The reaction was filtered to remove the yellow solid which was washed with tetrahydrofuran and recrystallized from 20 mL of boiling methanol to afford 0.060 g of the desired product, mp >250° C.

1. additionWhen the addition
2. customthe ice bath was removed
3. filtrationThe reaction was filtered
4. customto remove the yellow solid which
5. washwas washed with tetrahydrofuran
6. customrecrystallized from 20 mL of boiling methanol