HRID50746

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID7172308

4-Bromo-2-fluorobenzyl cyanide

C8H5BrFN

HCID10987806

(4,4-Dimethyl-2-oxo-1,4-dihydro-2H-3,1-benzoxazin-6-yl)boronic acid

C10H12BNO4

PRODUCTS

生成物

结构：CC1(C)OC(=O)Nc2ccc(-c3ccc(CC#N)c(F)c3)cc21

HCID23509618

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID962

Water

H2O

PROCEDURE

实验过程

Prepared according to procedure B from 4-bromo-2-fluorophenylacetonitrile (T. Alessi A. H. P. U.S. Pat. No. 4,895,862) and (1,4-dihydro-4,4-dimethyl-2-oxo-2H-3,1-benzoxazin-6-yl)boronic acid. A grey solid; mp 253-256° C. 1H NMR (DMSO-d6) δ 10.35 (s, 1H) 7.67-7.49 (m, 5H), 6.97 (d, 1H, J=8.6 Hz) 4.09 (s, 2H) 1.67(s, 6H), MS [M−H]−m/z 309. Anal. Calc. For C18H15N2FO2.0.15 H2O: C, 69.07; H, 4.93; N, 8.95. Found C, 69.27; H 5.05; N, 8.50.

WORKUP

后处理

customPrepared