反应详情

温度

100 °C

A mixture of 2-fluoro-4-nitrobenzamide (0.83 g, 4.6 mmol) and phosphorus pentoxide/hexamethyl disiloxane in 1,2-dichloroethane (20 mL) was heated under nitrogen at 100° C. for 4 hours. Upon cooling, the solution was poured onto a plug of silica gel and washed with hexane (200 mL) followed by 5% methanol/chloroform (400 mL). The methanol/chloroform washes were collected and concentrated under reduced pressure to give 2-fluoro-4-nitrobenzonitrile (0.71 g, 95%) as a beige solid.

1. temperatureUpon cooling
2. additionthe solution was poured onto a plug of silica gel
3. washwashed with hexane (200 mL)
4. customThe methanol/chloroform washes were collected
5. concentrationconcentrated under reduced pressure