反应详情

To a mixture of ethyl 4-[6-acetyl-3-[3-(4-acetyl-3-hydroxy -2-propylphenylthio)propoxy]-2-propylphenoxy]butyrate (2.1 g) in ethanol (10 ml) was added a solution of sodium hydroxide (0.26 g) dissolved into water (10 ml). After heating on a hot water bath for 5 minutes, the mixture was cooled by adding ice-water and was made acidic by addition of hydrochloric acid, followed by extraction with ethyl acetate. The organic layer was washed with water, dried over sodium sulfate and concentrated. The resultant residue was separated and purified by silica-gel column chromatography (eluting with ethanol:methylene chloride=3:100) to give the title compound (1.3 g, 65.2%) as colorless crystals, mp 79-81° C.

1. temperatureAfter heating on a hot water bath for 5 minutes
2. temperaturethe mixture was cooled
3. extractionfollowed by extraction with ethyl acetate
4. washThe organic layer was washed with water
5. dry with materialdried over sodium sulfate
6. concentrationconcentrated
7. customThe resultant residue was separated
8. custompurified by silica-gel column chromatography (eluting with ethanol:methylene chloride=3:100)