HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 1-(2-aminoethyl)-2,3-dihydro-2-oxo-1H-benzimidazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | tert-Butyl 2-(2-oxo-2,3-dihydrobenzo[d]imidazol-1-yl)ethylcarbamate | HCID 57428815 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Product | 1-(2-aminoethyl)-2,3-dihydro-2-oxo-1H-benzimidazole | HCID 11745176 | — |
Reaction Steps
tert-Butyl 2-(2-oxo-2,3-dihydrobenzo[d]imidazol-1-yl)ethylcarbamate (200 mg) was added to 15 mL of hydrogen chloride solution in diethyl ether (1 M) and the mixture was stirred at rt for 5 h. Evaporation of the solvent give the title compound as a white hydrochloride salt (100%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07786132B2 |
| Source dataset | uspto-grants-2010_08 |
| ORD ID | ord-01e96bcf7dab41fc867ccac764bceff9 |
| Source note | uspto-grants-2010_08 |