Hydrochloric Acid → 1-(2-aminoethyl)-2,3-dihydro-2-oxo-1H-benzimidazole

HRID 507513Notes

Reaction equation

HRID 507513 reaction equation
[O:1]=[C:2]1[N:6]([CH2:7][CH2:8][NH:9]C(=O)OC(C)(C)C)[C:5]2[CH:17]=[CH:18][CH:19]=[CH:20][C:4]=2[NH:3]1.Cl>C(OCC)C>[NH2:9][CH2:8][CH2:7][N:6]1[C:5]2[CH:17]=[CH:18][CH:19]=[CH:20][C:4]=2[NH:3][C:2]1=[O:1]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 57428815tert-Butyl 2-(2-oxo-2,3-dihydrobenzo[d]imidazol-1-yl)ethylcarbamate

Product 1

HCID 117451761-(2-aminoethyl)-2,3-dihydro-2-oxo-1H-benzimidazole

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

tert-Butyl 2-(2-oxo-2,3-dihydrobenzo[d]imidazol-1-yl)ethylcarbamate (200 mg) was added to 15 mL of hydrogen chloride solution in diethyl ether (1 M) and the mixture was stirred at rt for 5 h. Evaporation of the solvent give the title compound as a white hydrochloride salt (100%).

Workup

  1. customEvaporation of the solvent

Sources & evidence

ORD record
ord-01e96bcf7dab41fc867ccac764bceff9
Source dataset
uspto-grants-2010_08
Patent number
US07786132B2

Reaction notes

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