反应详情

A solution of 2.0 g (15.6 mmol) of 2-thiopheneboronic acid in 80 mL of a 5% (w/v) Na2CO3 aqueous solution was added drop wise to a refluxing solution of 4.7 g (31 mmol) of 2,4-dichloropyrimidine and 0.55 g (0.78 mmol) of bis(triphenylphosphine)palladium(II) chloride in 80 mL of MeCN. The reaction solution was heated at reflux for 6 h, then cooled to rt, the organic solvent removed in vacuo, and the resulting purple solid filtered and washed with water. The crude product was purified by flash chromatography eluting with a linear gradient of neat hexane to neat EtOAc to deliver the title compound. MS (M+H)+ 197.

1. temperatureThe reaction solution was heated
2. temperatureat reflux for 6 h
3. customthe organic solvent removed in vacuo
4. filtrationthe resulting purple solid filtered
5. washwashed with water
6. customThe crude product was purified by flash chromatography
7. washeluting with a linear gradient of neat hexane to neat EtOAc