反应详情

温度

55 °C

1-(Thiophen-2-yl)propan-1-one (0.15 g, 1.069 mmol) was treated with tert-butoxybis-(dimethylamino)methane (0.5 mL) and the mixture stirred at 55° C. overnight. The volatiles were removed in vacuo and the residual liquid was azeotroped with toluene. The resulting residue was dissolved in ethyl acetate and passed through a plug of silica gel. The filtrate was concentrated and placed under vacuum to afford a thick yellow oil. Yield=0.2 g. MS (M+H)+ 196.

1. customThe volatiles were removed in vacuo
2. customthe residual liquid was azeotroped with toluene
3. dissolutionThe resulting residue was dissolved in ethyl acetate
4. concentrationThe filtrate was concentrated
5. customto afford a thick yellow oil