2-Propionylthiophene → 3-(Dimethylamino)-2-methyl-1-(2-thienyl)-2-propen-1-one

Beteiligte Stoffe

Reaktionsbedingungen

Reaktionsschritte

1-(Thiophen-2-yl)propan-1-one (0.15 g, 1.069 mmol) was treated with tert-butoxybis-(dimethylamino)methane (0.5 mL) and the mixture stirred at 55° C. overnight. The volatiles were removed in vacuo and the residual liquid was azeotroped with toluene. The resulting residue was dissolved in ethyl acetate and passed through a plug of silica gel. The filtrate was concentrated and placed under vacuum to afford a thick yellow oil. Yield=0.2 g. MS (M+H)+ 196.

Herkunft & Nachweise