7-Methylcoumarin → 7-(Bromomethyl)-2h-chromen-2-one

HRID 507788노트

반응식

HRID 507788 반응식
[CH3:1][C:2]1[CH:11]=[C:10]2[C:5]([CH:6]=[CH:7][C:8](=[O:12])[O:9]2)=[CH:4][CH:3]=1.[Br:13]N1C(=O)CCC1=O>>[Br:13][CH2:1][C:2]1[CH:11]=[C:10]2[C:5]([CH:6]=[CH:7][C:8](=[O:12])[O:9]2)=[CH:4][CH:3]=1

참가 물질

3

반응물 2

HCID 171317-MethylcoumarinHCID 67184N-bromobutanimide

생성물 1

HCID 2641197-(Bromomethyl)-2h-chromen-2-one수율 101.8%

반응 조건

온도
78 °C

실험 절차

To a solution of 7-methylcoumarin (50 g) in acetonitorile (1.2 L) were added N-bromosuccinimide (56 g) α,α′-azobisisobutyronitrile (510 mg) and the mixture was stirred at 78° C. for 30 minutes. The reaction solution was concentrated and then added water (1 L). The appeared crystal was filtrated to give the title compound (76 g) having the following physical data.

후처리

  1. concentrationThe reaction solution was concentrated
  2. filtrationThe appeared crystal was filtrated

출처 및 근거

ORD 기록
ord-b750719e6fab494bbe924a3dc2802e17
출처 데이터셋
uspto-grants-2010_08
특허 번호
US07786161B2

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