Hydrochloric Acid → HCID 68622606, compound

HRID 507837Notes

Reaction equation

HRID 507837 reaction equation
[CH3:1][C:2]([CH3:40])([CH3:39])[C:3]([NH:5][CH2:6][C@@H:7]([C@@H:9]([NH:31]C(=O)OC(C)(C)C)[CH2:10][C@H:11]([CH2:15][NH:16][C:17](=[O:30])[C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=1[O:24][CH2:25][CH2:26][CH2:27][O:28][CH3:29])[CH:12]([CH3:14])[CH3:13])[OH:8])=[O:4].[ClH:41]>>[ClH:41].[NH2:31][C@H:9]([C@@H:7]([OH:8])[CH2:6][NH:5][C:3](=[O:4])[C:2]([CH3:40])([CH3:39])[CH3:1])[CH2:10][C@@H:11]([CH:12]([CH3:14])[CH3:13])[CH2:15][NH:16][C:17](=[O:30])[C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=1[O:24][CH2:25][CH2:26][CH2:27][O:28][CH3:29]

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 86613456HCID 86613456, compound

Product 1

HCID 68622606HCID 68622606, compound

Procedure

The solution of 0.030 g of tert-butyl (1(S)-[2-(2,2-dimethylpropionylamino)-1(S)-hydroxyethyl]-3(S)-{[2-(3-methoxypropoxy)benzoylamino]methyl}-4-methylpentyl)carbamate in 1 ml of 4M HCl (in dioxane) is stirred at 0° C. to 20° C. over 2 hours, subsequently concentrated by evaporation to dryness—the residue is dissolved in 1 ml of tert-butanol, frozen and lyophilized under high vacuum. The title compound is obtained as a white powder. Rf=0.20 (200:20:1 dichloromethane-methanol-25% conc. ammonia); Rt=3.55 (gradient I).

Workup

  1. concentrationsubsequently concentrated by evaporation to dryness—the residue
  2. dissolutionis dissolved in 1 ml of tert-butanol
  3. temperaturefrozen

Sources & evidence

ORD record
ord-ba380eea49f640dea432a71d93dcd3d9
Source dataset
uspto-grants-2010_08
Patent number
US07786307B2

Reaction notes

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