反应详情

A mixture of 5-bromoindan-1-one (1.20 g, 5.69 mmol), 2,6-dimethylphenylboronic acid (1.02 g, 6.82 mmol), tetrakis(triphenylphosphine)palladium(0) (328 mg, 0.285 mmol), sodium carbonate (1.81 g, 17.1 mmol), methanol (8 mL), water (8 mL) and toluene (25 mL) was heated under reflux overnight under an argon atmosphere. After cooling, the reaction mixture was diluted with ethyl acetate, washed with water, dried and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (5%-50% ethyl acetate/hexane) to give the title compound (0.73 g, yield 54%) as a colorless oil.

1. temperaturewas heated
2. temperatureunder reflux overnight under an argon atmosphere
3. temperatureAfter cooling
4. washwashed with water
5. customdried
6. concentrationconcentrated under reduced pressure
7. customThe residue was purified by silica gel column chromatography (5%-50% ethyl acetate/hexane)