Ethyl 6-(acetylamino)-4'-(benzyloxy)-2',6'-dimethylbiphenyl-3-carboxylate → HCID 23157389, compound

HRID 508017Notes

Reaction equation

HRID 508017 reaction equation
[C:1]([NH:4][C:5]1[C:10]([C:11]2[C:16]([CH3:17])=[CH:15][C:14]([O:18]CC3C=CC=CC=3)=[CH:13][C:12]=2[CH3:26])=[CH:9][C:8]([C:27]([O:29][CH2:30][CH3:31])=[O:28])=[CH:7][CH:6]=1)(=[O:3])[CH3:2]>[C].[Pd].C(O)C>[C:1]([NH:4][C:5]1[C:10]([C:11]2[C:12]([CH3:26])=[CH:13][C:14]([OH:18])=[CH:15][C:16]=2[CH3:17])=[CH:9][C:8]([C:27]([O:29][CH2:30][CH3:31])=[O:28])=[CH:7][CH:6]=1)(=[O:3])[CH3:2]

Participants

4

Reactant 1

HCID 23157386Ethyl 6-(acetylamino)-4'-(benzyloxy)-2',6'-dimethylbiphenyl-3-carboxylate

Product 1

HCID 23157389HCID 23157389, compoundYield 86%

Reagents, catalysts & solvents 2

HCID 178418390HCID 178418390, compoundCatalystHCID 702EthanolSolvent

Procedure

A mixture of ethyl 6-(acetylamino)-4′-(benzyloxy)-2′,6′-dimethylbiphenyl-3-carboxylate (809 mg, 1.94 mmol), 10% palladium-carbon (50% water-containing product, 404 mg) and ethanol (10 mL) was stirred overnight under a hydrogen atmosphere at room temperature. The catalyst was filtered off, and the filtrate was concentrated under reduced pressure to give the title compound (544 mg, yield 86%) as colorless crystals.

Workup

  1. filtrationThe catalyst was filtered off
  2. concentrationthe filtrate was concentrated under reduced pressure

Sources & evidence

ORD record
ord-1e2601321a1a46dbb5ae559a80275a86
Source dataset
uspto-grants-2010_08
Patent number
US07786165B2

Reaction notes

Loading…