Hydrogen chloride-ethyl acetate → HCID 68718963, compound

HRID 508029Notes

Reaction equation

HRID 508029 reaction equation
[ClH:1].C(OCC)(=O)C.[C:8]1([C:14]2[N:15]=[C:16]([N:19]([CH2:23][C:24]3[CH:42]=[CH:41][C:27]([CH2:28][NH:29][C:30]4[CH:35]=[CH:34][C:33]([CH2:36][CH2:37][C:38]([OH:40])=[O:39])=[CH:32][CH:31]=4)=[CH:26][CH:25]=3)[CH2:20][CH2:21][CH3:22])[S:17][CH:18]=2)[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1>C(OCC)(=O)C>[ClH:1].[ClH:1].[C:8]1([C:14]2[N:15]=[C:16]([N:19]([CH2:23][C:24]3[CH:25]=[CH:26][C:27]([CH2:28][NH:29][C:30]4[CH:31]=[CH:32][C:33]([CH2:36][CH2:37][C:38]([OH:40])=[O:39])=[CH:34][CH:35]=4)=[CH:41][CH:42]=3)[CH2:20][CH2:21][CH3:22])[S:17][CH:18]=2)[CH:9]=[CH:10][CH:11]=[CH:12][CH:13]=1

Participants

4

Reactant 2

HCID 21866389Hydrogen chloride-ethyl acetateHCID 23157192HCID 23157192, compound

Product 1

HCID 68718963HCID 68718963, compoundYield 98%

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

4 N Hydrogen chloride/ethyl acetate solution (1.25 mL) was added to a solution of 3-{4-[(4-{[(4-phenyl-1,3-thiazol-2-yl)(propyl)amino]methyl}benzyl)amino]phenyl}propanoic acid (0.496 g, 1.02 mmol) in ethyl acetate (3.75 mL), and the resulting solid was pulverized and washed with ethyl acetate-diethyl ether to give the title compound as pale-yellow crystals (0.558 g, yield 98%).

Workup

  1. washwashed with ethyl acetate-diethyl ether

Sources & evidence

ORD record
ord-b378977201fa4bd5b5f3f09e64954489
Source dataset
uspto-grants-2010_08
Patent number
US07786165B2

Reaction notes

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