反应详情

To a solution of 3-[4-({[4′-(2-ethoxyethoxy)-2′,6′-dimethylbiphenyl-3-yl]methyl}amino)phenyl]propanoic acid (0.736 g, 1.64 mmol) in ethyl acetate (3.75 mL) was added 4 N hydrogen chloride/ethyl acetate solution (1.25 mL), and the resulting solid was pulverized and washed with ethyl acetate-diethyl ether to give the title compound as colorless crystals (0.762 g, yield 96%).

1. washwashed with ethyl acetate-diethyl ether