Sodium Hydroxide → HCID 87548979, compound

Participants

Reaction Steps

3-[4-({4-[(2,2-Dimethylquinolin-1(2H)-yl)methyl]-3-isopropoxybenzyl}amino)-2-fluorophenyl]propanoic acid (0.12 g, 0.24 mmol) was dissolved in methanol (2 mL), and 1 N aqueous sodium hydroxide solution (0.24 mL, 0.24 mmol) was added. A solution of calcium chloride (13 mg, 0.12 mmol) in water (1 mL) was added, and the precipitated solid was collected by filtration, washed with water and methanol and dried to give the title compound (53 mg, yield 43%) as a colorless powder.

Provenance & Evidence