Sodium Hydroxide → HCID 87548979, compound

HRID 508087Notes

Reaction equation

HRID 508087 reaction equation
[CH3:1][C:2]1([CH3:37])[CH:11]=[CH:10][C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[N:3]1[CH2:12][C:13]1[CH:32]=[CH:31][C:16]([CH2:17][NH:18][C:19]2[CH:24]=[CH:23][C:22]([CH2:25][CH2:26][C:27]([OH:29])=[O:28])=[C:21]([F:30])[CH:20]=2)=[CH:15][C:14]=1[O:33][CH:34]([CH3:36])[CH3:35].[OH-].[Na+].[Cl-].[Ca+2:41].[Cl-]>CO.O>[Ca+2:41].[CH3:1][C:2]1([CH3:37])[CH:11]=[CH:10][C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[N:3]1[CH2:12][C:13]1[CH:32]=[CH:31][C:16]([CH2:17][NH:18][C:19]2[CH:24]=[CH:23][C:22]([CH2:25][CH2:26][C:27]([O-:29])=[O:28])=[C:21]([F:30])[CH:20]=2)=[CH:15][C:14]=1[O:33][CH:34]([CH3:35])[CH3:36].[CH3:1][C:2]1([CH3:37])[CH:11]=[CH:10][C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[N:3]1[CH2:12][C:13]1[CH:32]=[CH:31][C:16]([CH2:17][NH:18][C:19]2[CH:24]=[CH:23][C:22]([CH2:25][CH2:26][C:27]([O-:29])=[O:28])=[C:21]([F:30])[CH:20]=2)=[CH:15][C:14]=1[O:33][CH:34]([CH3:35])[CH3:36]

Participants

6

Reactant 3

HCID 14798Sodium HydroxideHCID 5284359Calcium ChlorideHCID 23157371HCID 23157371, compound

Product 1

HCID 87548979HCID 87548979, compoundYield 43%

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 962WaterSolvent

Procedure

3-[4-({4-[(2,2-Dimethylquinolin-1(2H)-yl)methyl]-3-isopropoxybenzyl}amino)-2-fluorophenyl]propanoic acid (0.12 g, 0.24 mmol) was dissolved in methanol (2 mL), and 1 N aqueous sodium hydroxide solution (0.24 mL, 0.24 mmol) was added. A solution of calcium chloride (13 mg, 0.12 mmol) in water (1 mL) was added, and the precipitated solid was collected by filtration, washed with water and methanol and dried to give the title compound (53 mg, yield 43%) as a colorless powder.

Workup

  1. filtrationthe precipitated solid was collected by filtration
  2. washwashed with water and methanol
  3. customdried

Sources & evidence

ORD record
ord-9dcef81f15e544a59a7b4ce404156b52
Source dataset
uspto-grants-2010_08
Patent number
US07786165B2

Reaction notes

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