Sodium Hydroxide → HCID 87549243, compound

Participants

Reaction Steps

To a solution of 3-{4-[({6-(acetylamino)-4′-[(4-hydroxy-1,1-dioxidotetrahydro-2H-thiopyran-4-yl)methoxy]-2′,6′-dimethylbiphenyl-3-yl}methyl)amino]-2-fluorophenyl}propanoic acid (86.3 mg, 0.14 mmol) in methanol (1 mL) was added 1 M sodium hydroxide solution (0.14 mL). Successively, an aqueous solution of calcium chloride (8.7 mg, 0.07 mmol) was gradually added. The precipitated solid was collected by filtration, washed with water, and vacuum dried to give the title compound (39.2 mg, yield 44%) as a colorless amorphous powder.

Provenance & Evidence